Acute hepatitis following mRNA BNT162b2 COVID-19 vaccination
نویسندگان
چکیده
BACKGROUND: Widespread administration of COVID-19 vaccinations have led to reports rare but potentially serious side effects. METHODS: We present two cases acute hepatitis following mRNA BNT162b2 (Comirnaty, Pfizer-BioNTech) vaccination. RESULTS: A 25-year-old male presented hospital with progressive jaundice 5 days his second dose Comirnaty. Initial bloodwork revealed severe hepatocellular enzyme elevation and conjugated hyperbilirubinemia preserved INR. Extensive serologic workup was negative, normal imaging. Percutaneous liver biopsy performed cholestatic possibly related drug-induced injury. He started on prednisone 40 mg daily good initial response had a flare; repeated which showed near-identical findings. Steroids were discontinued given non-response the patient gradual near complete resolution enzymes hyperbilirubinemia. 32-year-old 4-week history nausea followed by choluria, jaundice, pruritis. received Comirnaty vaccination weeks prior presentation. mixed Serological imaging unrevealing. underwent intrahepatic cholestasis, injury being suggested as most likely cause. His course self-limited serological abnormalities symptoms. CONCLUSIONS: While overwhelmingly safe population level, our case series illustrate icteric Clinicians should be aware this association hepatic inflammation consider vaccine an important component evaluating patients
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ژورنال
عنوان ژورنال: Canadian liver journal
سال: 2022
ISSN: ['2561-4444']
DOI: https://doi.org/10.3138/canlivj-2022-0014